Corning Permeable Support Systems | HTS Insert Plates | Corning

About

Overview

Compatible with most robotics and fluid handlers, our automation friendly HTS systems increase growth area and yield. Each is packaged complete with reservoir and receiver plates, so there's no need to purchase parts separately. Customized products are available to meet special requirements.

Corning also offers high throughput screening (HTS) insert plates. These are arrays of individual cell culture inserts connected by a rigid, robotics-friendly holder. This single-unit design makes insert plates ideal for running automated, high throughput drug transport (Caco-2 cells) cell toxicity studies or cell migration and invasion studies.

Corning HTS insert plates and systems feature inserts with aour unique self-centering hanging insert design, which prevents media from wicking between insert and plate well. The design of the inserts It also keeps the membrane just off the well bottom, preventing co-cultured cell monolayers in the lower compartment from being damaged when the insert is moved. Openings in the sides of the insert allow easy access to the lower compartment.

Products

Permeable Support HTS Plates and Systems

Characteristics

Uncoated and Coated HTS Insert Plates

Transwell Plates

HTS insert plates are arrays of individual cell culture inserts connected by a rigid, robotics-friendly holder. This single-unit design makes insert plates ideal for running automated, high throughput drug transport (Caco-2 cells) cell toxicity studies or cell migration and invasion studies.

HTS insert plates are arrays of individual cell culture inserts connected by a rigid, robotics-friendly holder. This single-unit design makes insert plates ideal for running automated, high throughput drug transport (Caco-2 cells) cell toxicity studies or cell migration and invasion studies.

Pore Size (μm)

0.4

0.4

1.0

3.0

5.0

8.0

Membrane

PET

PC

PET

PC

PC

PET

Pore Density

4 x 106

1 x 108

1.6 x 106

2 x 106

4 x 105

1 x 105

Opacity

Clear

Translucent

Clear

Translucent

Translucent

Clear

24-wellxxxx  
96-well xxxxx
Falcon Plates

HTS insert plates are arrays of individual cell culture inserts connected by a rigid, robotics-friendly holder. This single-unit design makes insert plates ideal for running automated, high throughput drug transport (Caco-2 cells) cell toxicity studies or cell migration and invasion studies.

HTS insert plates are arrays of individual cell culture inserts connected by a rigid, robotics-friendly holder. This single-unit design makes insert plates ideal for running automated, high throughput drug transport (Caco-2 cells) cell toxicity studies or cell migration and invasion studies.

Pore Size (μm)

1.0

3.0

3.0

8.0

8.0

Membrane

PET

PET

FluoroBlok™ PET

PET

FluoroBlokPET

Pore Density

1.6 x 106

8 x 105

8 x 105

1 x 105

1 x 105

Opacity

Clear

Clear

Light-blocking

Clear

Light-blocking

24-well

x

x

x

x

x

96-well  xxx
Coated HTS Plates

Pore Size (μm)

 

1.0

3.0

8.0

Membrane

 

PET

PET

FluoroBlok

FluoroBlok

FluoroBlok

System   Angiogenesis cell migration systemaAngiogenesis cell invasion systembTumorcell invasion systemc
Coatings      
Fibrillar Collagen I x    
Fibronectin  xx  
Corning® Matrigel® Matrix    xx
Phospholipids      

Pore Density

 

1.6 x 106

8 x 105

8 x 105

8 x 105

6 x 104

Brand

 

BioCoat™

BioCoat

BioCoat

BioCoat

BioCoat

24-well xxxxx
96-well   x x

a Angiogenesis cell migration system: Use to evaluate endothelial cell invasion using real-time fluorescence detection in a simplified and reproducible manner. Increase screening throughput for prospective pro- and anti-angiogenic compounds. Tested for its ability to allow invasion of HUVEC cells in response to VEGF. This system consists of a receiver plate, a lid, and a Falcon Multiwell Insert Plate with 3.0μm Corning FluoroBlok membrane coated with human Fibronectin.

b Angiogenesis cell invasion system: A quantitative and reproducible in vitro model system for examining the effects of prospective compounds on endothelial cell migration. Tested for its ability to allow invasion of HMVEC-1 cells and to exclude invasion of NIH-3T3 cells. This system consists of a receiver plate, a lid, and a Falcon Multiwell Insert Plate with 3.0μm FluoroBlok membrane coated with Matrigel matrix.

c Tumor cell invasion system: An in vitro system for the study of cell invasion through a basement membrane. The system consists of Falcon inserts containing an 8 um pore size PET membrane coated with a uniform layer of Matrigel matrix.

Featured Resources

The Progession of Cancer

The Progession of Cancer

The Progession of Cancer

This poster follows the progression of cancer from tumor formation to angiogenesis through intravasation/metastasis/extravasation. Corning products that support research at each stage are highlighted.

This poster follows the progression of cancer from tumor formation to angiogenesis through intravasation/metastasis/extravasation. Corning products that support research at each stage are highlighted.

Learn More
Culture and Assay Systems

Culture and Assay Systems Used for 3D Cell Culture

Culture and Assay Systems Used for 3D Cell Culture

This whitepaper focuses on general principles, advantages, and caveats of in vitro 3D cell culture systems.

This whitepaper focuses on general principles, advantages, and caveats of in vitro 3D cell culture systems.

Learn More
HTS Transwell

HTS Transwell System

HTS Transwell 96-well Tissue Culture System

Ideal for ADME screening, drug transport, and other assays, our 96-well systems provide up to 50% more surface area and are optimized for automation.

Ideal for ADME screening, drug transport, and other assays, our 96-well systems provide up to 50% more surface area and are optimized for automation.

Learn More
Corning HTS Transwell

Corning HTS Transwell

Corning HTS Transwell-96 Permeable Support

This is one of the many protocols that are being provided as a starting point for such drug transport assays as those utilizing the Caco-2 cell line.

This is one of the many protocols that are being provided as a starting point for such drug transport assays as those utilizing the Caco-2 cell line.

Learn More
A Quick Look at Transwell® Permeable Supports

Permeable Supports

A Quick Look at Transwell® Permeable Supports

Watch this short video to see how our patented self-centering design ensures that the insert hangs perfectly to prevent wicking and cell damage.

Watch this short video to see how our patented self-centering design ensures that the insert hangs perfectly to prevent wicking and cell damage.

Watch Now
25 Tips and Techniques for Transwell Permeable

25 Tips for Transwell

25 Tips & Techniques for Transwell Supports

Transwell permeable supports have been a lab standard for decades. Over that time, we’ve accumulated numerous tips and techniques. Check out these top 25 favorites.

Transwell permeable supports have been a lab standard for decades. Over that time, we’ve accumulated numerous tips and techniques. Check out these top 25 favorites.

Learn More

Select in Four Easy Steps

Four Easy Steps to Selecting the Optimal Insert

Corning gives you countless ways to advance your potential for discovery, with our selection guide making it easy to choose the membrane, pore size, format, and surface to meet your specific needs.

Corning gives you countless ways to advance your potential for discovery, with our selection guide making it easy to choose the membrane, pore size, format, and surface to meet your specific needs.

Learn More

Cell Migration and Invasion with Transwell Permeable Supports

Cell Migration and Invasion with Transwell Permeable Supports

In vitro cell migration and invasion assays are frequently used as model systems to quantify the directed movement of cells towards a chemoattractant stimulus or to measure how a particular drug, antibody or extracellular matrix (ECM) coating affects movement of cells.

In vitro cell migration and invasion assays are frequently used as model systems to quantify the directed movement of cells towards a chemoattractant stimulus or to measure how a particular drug, antibody or extracellular matrix (ECM) coating affects movement of cells.

Watch Now
Transwell Permeable Supports from Corning: One Research Tool Used 5 Ways

Transwell Permeable Supports from Corning: One Research Tool Used 5 Ways

Transwell Permeable Supports from Corning: One Research Tool Used 5 Ways

Learn about different ways to use Transwell permeable supports, from drug screening to invasion assays.

Learn about different ways to use Transwell permeable supports, from drug screening to invasion assays.

Download

How to Choose, How to Use, & How to Buy

Next Steps

Order Now
Order Now

Order Now

Order Now

Order Now

Just browse our online catalog, and add products directly to your cart.

Just browse our online catalog, and add products directly to your cart.

Order Now
How to Choose
Choose

How to Choose

How to Choose

Learn More

Advance discovery in your lab by choosing the right permeable support HTS plate or system for your exact high throughput requirements.

Advance discovery in your lab by choosing the right permeable support HTS plate or system for your exact high throughput requirements.

Learn More
How to Use
How to Use

How to Use

How to Use

Learn More

From protocols and webinars to onsite technical demos and custom capabilities, our experts are available to help get your research up and running, providing complete support along the way.

From protocols and webinars to onsite technical demos and custom capabilities, our experts are available to help get your research up and running, providing complete support along the way.

Learn More
Distributors
Distributors

Distributors

Distributors

Learn More

Many distributors offer our full line of permeable support HTS plates and systems. 

Many distributors offer our full line of permeable support HTS plates and systems. 

Learn More
Customer Service
Customer Service

Customer Service

Customer Service

Contact Us

If you need assistance selecting HTS plates or systems, or if you’d like to order by phone, fax, or email, contact us.

If you need assistance selecting HTS plates or systems, or if you’d like to order by phone, fax, or email, contact us.

Contact Us

Products

Related Permeable Support Products

Corning® FluoroBlok™ Insert Systems

Corning® FluoroBlok™ Insert Systems Corning® FluoroBlok™ Insert Systems

These systems are ideal for tumor cell invasion and endothelial cell migration and invasion assays. Light-tight PET membranes allow fluorescence detection in a simplified, non-destructive manner.

These systems are ideal for tumor cell invasion and endothelial cell migration and invasion assays. Light-tight PET membranes allow fluorescence detection in a simplified, non-destructive manner.

Order Now
Corning BioCoat Angiogenesis and Tumor Invasion

Corning BioCoat Angiogenesis and Tumor Invasion Corning BioCoat Angiogenesis and Tumor Invasion

These optimized systems are available for in vitro angiogenesis and tumor cell invasion assays. Corning BioCoat tumor invasion systems are pre-coated with Matrigel®, providing a consistent protein.

These optimized systems are available for in vitro angiogenesis and tumor cell invasion assays. Corning BioCoat tumor invasion systems are pre-coated with Matrigel®, providing a consistent protein.

Order Now
Connect With Corning

Connect With Corning

Connect With Corning

Contact Us