3D Organoid Culture Models | Corning

Cancers occur due to accumulations of genetic mutations and the organoid platform has often been leveraged to gain better understanding of such mutational signatures. Organoids have been generated from diverse human cancers, including breast, colon, pancreas, prostate, bladder, and liver. These organoid models hold tremendous potential to mimic pathophysiology of human tumors. Shown is an example of organoid generation from the prostate gland.

Cancers occur due to accumulations of genetic mutations and the organoid platform has often been leveraged to gain better understanding of such mutational signatures. Organoids have been generated from diverse human cancers, including breast, colon, pancreas, prostate, bladder, and liver. These organoid models hold tremendous potential to mimic pathophysiology of human tumors. Shown is an example of organoid generation from the prostate gland.

The development of the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-Cas9 genome editing technology enables fast genome engineering. It can edit DNA at precise locations faster, more accurate and more efficiently than existing genome editing methods. When combined with organoid technology, it allows for better genetic and drug screening models and opportunities to study organ development.

The development of the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)-Cas9 genome editing technology enables fast genome engineering. It can edit DNA at precise locations faster, more accurate and more efficiently than existing genome editing methods. When combined with organoid technology, it allows for better genetic and drug screening models and opportunities to study organ development.

Personalized medicine enables targeted treatment for an individual at a molecular and pharmacogenomic level to maximize the effect of a treatment. Organoids, derived from an individual’s stem cells, progenitor cells or from induced pluripotent stem cells, can be used for disease modeling, to test the efficiency and dosage of a drug, and for regenerative medicine.

Personalized medicine enables targeted treatment for an individual at a molecular and pharmacogenomic level to maximize the effect of a treatment. Organoids, derived from an individual’s stem cells, progenitor cells or from induced pluripotent stem cells, can be used for disease modeling, to test the efficiency and dosage of a drug, and for regenerative medicine.

Drug discovery uses a combination of in vitro and in vivo models, including organoids to identify possible drug candidates. Drug Discovery is a lengthy and expensive procedure that screens millions of compounds for a selective few active ingredients that can be developed into medicine used to treat specific diseases.

Drug discovery uses a combination of in vitro and in vivo models, including organoids to identify possible drug candidates. Drug Discovery is a lengthy and expensive procedure that screens millions of compounds for a selective few active ingredients that can be developed into medicine used to treat specific diseases.

Organ-on-a-chip are microdevices with hollow microfluids channels lined with human organ specific cells interfaced with human endothelial vasculature. This imitates the microarchitecture and function of living human organs and is a human in vivo model for drug testing.

Organ-on-a-chip are microdevices with hollow microfluids channels lined with human organ specific cells interfaced with human endothelial vasculature. This imitates the microarchitecture and function of living human organs and is a human in vivo model for drug testing.