The Corning CellCube system provides a compact, perfusion-based method for the mass culture of attachment-dependent cells. CellCube modules are made of polystyrene plates joined together to create thin, sealed laminar flow spaces between adjacent plates and are coated with either a Tissue Culture-treated growth surface or Corning CellBIND® surface to enhance attachment. Utilizing a perfusion-based design, the CellCube system is able to mimic the constant fluid flow of in vivo conditions and reliably distribute nutrients and oxygen with low differential gradients across all attached cells throughout the modules. Corning also offers Closed system CellCube modules available pre-assembled with AseptiQuick® connectors, as well as aseptic circulation loops that facilitate cell culture scale-up.
Overview
Closely mimic in vivo conditions and increase cell growth and productivity for scale-up
Closely mimic in vivo conditions and increase cell growth and productivity for scale-up
Learn More About the CellCube System
How the CellCube system works:
How the CellCube system works:
The culture medium is perfused through the CellCube system by a peristaltic pump. This allows media to flow in from the controlled single use bioreactor (SUB) into the CellCube module and back to the SUB for conditioning. The controller system maintains the pH and dissolved oxygen (DO) levels of the perfused culture medium within the SUB to ensure consistent feeding of the cells in the CellCube modules.
*Peristaltic pump, SUB, and digital controller sold separately.
The culture medium is perfused through the CellCube system by a peristaltic pump. This allows media to flow in from the controlled single use bioreactor (SUB) into the CellCube module and back to the SUB for conditioning. The controller system maintains the pH and dissolved oxygen (DO) levels of the perfused culture medium within the SUB to ensure consistent feeding of the cells in the CellCube modules.
*Peristaltic pump, SUB, and digital controller sold separately.
Features and benefits of the CellCube system include:
Features and benefits of the CellCube system include:
- Surface treatment on both sides of the plates doubles the available surface area within the same footprint
- Encapsulation and endplates made from polycarbonate for strength and long-term reliability
- Flow control orifice and directors promote even distribution of media
- Scale-up from 8,500 cm2 to 85,000 cm2 is linear and uses the same pumps and controller for consistency and efficient scale-up
- Standardized closed system designs allow flexible setup of any CellCube module and aseptic connection to an oxygenator (sold separately)
- Sterile and ready-to-use offerings eliminate the time and complexity of assembling in-house
- Industry standard AseptiQuik S/G connectors allow for robust, single-use aseptic connections
- Surface treatment on both sides of the plates doubles the available surface area within the same footprint
- Encapsulation and endplates made from polycarbonate for strength and long-term reliability
- Flow control orifice and directors promote even distribution of media
- Scale-up from 8,500 cm2 to 85,000 cm2 is linear and uses the same pumps and controller for consistency and efficient scale-up
- Standardized closed system designs allow flexible setup of any CellCube module and aseptic connection to an oxygenator (sold separately)
- Sterile and ready-to-use offerings eliminate the time and complexity of assembling in-house
- Industry standard AseptiQuik S/G connectors allow for robust, single-use aseptic connections
Description | Cat. No. | Number of Layers | Growth Surface Area | Surface Treatment |
10 | 8,500 cm2 | Tissue Culture-treated | ||
25 | 21,250 cm2 | Tissue Culture-treated | ||
25 | 21,250 cm2 | Corning CellBIND | ||
100 | 85,000 cm2 | Tissue Culture-treated | ||
100 | 85,000 cm2 | Corning CellBIND |
Featured Resources
Resources
Achieving High Yield, Versatility, and Scalability for Adherent Cell Culture with Circulation/Perfusion Systems
Learn More: Achieving High Yield, Versatility, and Scalability for Adherent Cell Culture with Circulation/Perfusion SystemsLearn about circulation/perfusion adherent cell culture platforms and how Corning CellCube offers cost-effective, high-yield cell production.
The Race to Billions: How Amplifying Adherent Cultures Can Get You There
Learn More: The Race to Billions: How Amplifying Adherent Cultures Can Get You ThereLearn more about how adherent culture platforms can help you scale-up, while trimming time and costs with high-efficiency output.
Details and Ordering Information
Learn More: Details and Ordering InformationLearn more about the Corning CellCube system and how to order.
Maximizing Yield
Learn More: Maximizing YieldDiscover how to maximize yield for attachment-dependent cells with the Corning CellCube system.
Scalable High Yield System for Mass Culture of Attachment-Dependent Cells
Learn More: Scalable High Yield System for Mass Culture of Attachment-Dependent CellsRead about CellCube on Cell Culture Dish, including an interview with Dr. Ann Rossi.
Applications
Research Applications for the CellCube Culture System
Extracellular Vesicles
Learn More: Extracellular VesiclesCorning offers a line of products designed for large-scale of stem cell-derived extracellular vesicles (EVs) to impact regenerative medicine and the treatment of inflammatory conditions.
Vaccine Manufacturing
Learn More: Vaccine ManufacturingCorning provides a diverse set of single-use products for all your upstream vaccine manufacturing needs.
Bioprocess Applications
Learn More: Bioprocess ApplicationsBridge the gap between research, development, and production.
Cell Therapy
Learn More: Cell TherapyHarness the full potential of evolving cell and gene therapies, accelerate your research pipeline, and improve patient access to life-changing remedies.
Cell Culture
Learn More: Cell CultureCreate a more in vivo-like cell culture environment to advance your discoveries right, right from the start.
How to Buy
Purchasing Options
Order Now
It’s easy to purchase the Corning CellCube system. Simply contact Customer Service to set up an appointment with a Sales Specialist.
It’s easy to purchase the Corning CellCube system. Simply contact Customer Service to set up an appointment with a Sales Specialist.
Contact Us
If you need assistance purchasing the Corning CellCube system, or if you’d like to order by phone, fax, or email, please contact us.
If you need assistance purchasing the Corning CellCube system, or if you’d like to order by phone, fax, or email, please contact us.
Contact Us
If you’d like to see the Corning CellCube system in action, please contact us to request an in-person demonstration.
If you’d like to see the Corning CellCube system in action, please contact us to request an in-person demonstration.
