Cancer Intravasation, Metastasis, Extravasation Research, Tools, and Resources | Corning

The cancer metastasis process is multistep and includes local invasion, intravasation, transport, extravasation, and colonization.

Metastasis via Intravasation

During the intravasation process, tumor cells exit the tumor of origin and invade through the basement membrane and vessel walls into nearby lymphatic or blood vessels.

Secondary Tumor Formation via Extravasation

During extravasation, circulating tumor cells exit the lymphatic or blood vessels by invading through vessel walls and basement membrane into a new tissue or organ. These processes leave cancer cells vulnerable to circulating immune cells, mechanical forces and anoikis⁶. Yet, even with these challenges, cancer cells have found ways to protect themselves. Understanding these protective mechanisms might help us one day find ways to counter them.

Corning Products Help Researchers Study Tumor Metastasis Process

Corning supports cancer metastasis research with lab products that deliver consistent, repeatable results. Corning Matrigel^® matrix 3d plates and Corning BioCoat^®, fluoroblok, and transwell permeable supports are just a few of Corning products being used in metastasis research studies.

References:

_{6. Strilic, Boris and Stefan Offermanns. "Intravascular survival and extravasation of tumor cells." Cancer cell 32.3 (2017): 282-293.}